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Avocado is the best herbal treatment for hepatitis, dengue, HIV, and herpes

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Avocado

The antiviral properties of bamboo, moringa, lime, and alligator pepper are promising.

Recent research has shown that extracts from plants including avocado, bamboo, Moringa oleifera, lime, lemon, and alligator pepper can “treat” viral illnesses like herpes simplex, dengue fever, hepatitis, polio, yellow fever, measles, chickenpox, and HIV type one (HIV-1).

Until recently, it has been demonstrated that several regional plants have antibacterial and antiviral effects. Even though there isn’t a known cure for viral infections, researchers have found that there are several natural treatments that have been shown to help relieve symptoms and avoid side effects.

The plants are Vernonia amygdalina (bitter leaf), Garcinia kola (bitter kola), Citrus medica (lemon), Cymbopogon citratus (lemon grass), Moringa oleifera, Phyllanthus amarus, avocado (Persea Americana), and Gardonema mushroom. They also include Bambusa vulgaris (bamboo) and Aframomum melegueta (all).

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Researchers have also found that extracts from “bitter melon” (Momordica charantia), “pawpaw” (Carica papaya), “guava” (Psidium guajava), and “asthma herb” (Euphorbia hirta) might be able to “cure” viral infections.

According to the most recent study, avocado (Persea Americana) fruit extract suppresses dengue virus multiplication by enhancing NF-B-dependent activation of antiviral interferon responses. This research was published in the journal Scientific Reports in January 2019.

Until recently, the dengue virus (DENV) infected millions of people each year all over the world. The risk of dying from dengue hemorrhagic shock syndrome is thought to be 50% when multiple serotypes of DENV are co-infected. For the time being, there are no approved treatments for DENV infection. Novel anti-DENV drugs are thus desperately needed for medical treatment.

However, researchers have shown that a naturally occurring substance called (2 R,4 R)-1,2,4-trihydroxyheptadec-16-yne (THHY), which is extracted from the avocado fruit, can effectively suppress the replication of all DENV serotypes (1-4) and inhibit DENV-2 replication in a concentration-dependent manner. We further demonstrate that the inhibitory effect of THHY on DENV replication is mediated through the NF-B-driven interferon antiviral response. We discovered that THHY therapy led to a higher survival rate among DENV-infected mice using an ICR suckling animal model. “Taken together, these results suggest that THHY could be used to stop DENV infection,” they said.

The avocado, or Persea Americana, is a member of the Lauraceae family and is a common plant in tropical and subtropical areas. The avocado’s fruit, stem, and leaves are frequently utilized in traditional medicine. The avocado fruit, in particular, is rich in nutrients including vitamin E, vitamin B, potassium, and monounsaturated fatty acids, which have been shown to have a variety of bioactive qualities like antibacterial, antiviral, antioxidant, anti-atherosclerotic, hepatoprotective, and other actions. Monoterpenoids, sesquiterpenoids, triterpenoids, flavonoids, alkaloids, steroids, carotenoids, and long-chain fatty alcohol derivatives are among the bioactive substances found in avocados.

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Several compounds isolated from the unripe avocado fruit were subjected to drug screening in the current study, including oleic acid (OA), (2 R, 4 R)-1,2,4-trihydroxyheptadec-16-ene (THHE), (2 R, 4 R)-1,2,4-trihydroxyheptadec-16-yne (THHY), avocado A, avocado C, and avocadoin. It was discovered that “We identified the mechanism through which THHY prevents DENV infection by inducing NF-B-mediated antiviral IFN responses.” “Finally, using an ICR suckling mouse model infected with DENV, we looked at how well THHY might work as a food supplement to stop the deadly DENV virus from spreading,” they said.

Studies have also shown that avocado plant extracts can be used alone or with acyclovir to treat infections caused by the herpes simplex virus.

The journal Phytomedicine published the article “In vitro activity of extracts of Persea Americana leaves on acyclovir-resistant and phosphonoacetic-resistant Herpes simplex viruses.”

The acyclovir-resistant (ACGr4 and dlsp TK mutants) and PAA-resistant (PAAr5 mutant) herpes simplex viruses both showed a high inhibitory impact in response to the lyophilized aqueous crude extract (LACE) from leaves of Persea Americana species, according to the researchers. The soluble fraction was chromatographed on a reverse-phase column after LACE had been thoroughly washed with methanol, yielding 11 fractions that were identified using thin-layer chromatography. Analysis of the antiviral activity of the fractions revealed that the extract included chemicals that might prevent the replication of acyclovir-resistant HSV and extracellular viruses. From fractions 4 to 8, there was a concentration of the virucidal effect. Flavonoids like quercitrin and isoquercitrin dominate fractions 7 and 8, respectively. The main flavonoid in fraction 9, called afzelin, did not kill viruses but instead made them grow faster.

Another study showed the in-vitro virucidal and virustatic anti-HIV-1 properties of extracts from avocado leaves in the journal Antiviral Chemistry & Chemotherapy.

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The researchers are from the Department of Virology at the Federal University of Rio de Janeiro in Brazil as well as Academic Virology and Retroscreen Limited at the University of London’s London Hospital Medical College in the UK.

Cellular toxicity and anti-HIV-1 activity were examined for aqueous (PA1) and methanolic extracts (PA2a-d; PA3) from the tropical tree Persea Americana, both in virustatic and virucidal assays. Except for PA3 and PA2d, all of the extracts showed anti-HIV-1 activity at doses that did not harm the H9 indicator cells.

“Using reverse-phase column chromatography, we were able to separate the methanol-insoluble extract (PA2) into four different parts (PA2a–d), and two of those parts (b and c) had a clear antiviral effect.”At concentrations that didn’t hurt the indicator cells, one part (PA2a) acted like a virus and stopped the HIV syncytium and viral p24 antigen from growing.

The results show for the first time that leaf extracts from P. Americana have some mild anti-HIV-1 activity in a lab dish.

Patients with Acquired Immunodeficiency Syndrome (AIDS) have access to several antiviral drugs with virus-like activity. But as drug-resistant viruses have become more common, they have become less useful. This has renewed interest in drugs that kill viruses.

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Drugs that are virucidal interact with viruses directly and destroy virion. Virustatic medications, in contrast, typically operate intracellularly and block a crucial virus-enzyme or virus-coded function. HIV chemicals that kill the virus before it can attach to weak cells are the subject of a lot of research. These chemicals could be used as virus-killing creams in the vaginal and rectal areas to stop the virus from spreading.

The plant kingdom is a significant source of chemicals that can stop a variety of viruses from replicating. An extract taken from P. Americana leaves was investigated as part of a project looking for new viral inhibitors, in particular those having virucidal activity that can be separated. Traditional medicine has employed Persea Americana leaves as a diuretic and kidney stone remover. This is the first time that the anti-HIV-1 activity of this plant’s leaf extract in a lab setting is described.

Another study discovered that bamboo (Bambusa vulgaris), moringa oleifera, and lime seed (Citrus paridisi) could effectively combat the measles and herpes simplex viruses. The outcomes demonstrated that B. Vulgaris and M. oleifera n-hexane extracts suppressed the measles virus at doses of 0.125 and 0.016 g L-1, respectively. Similar to how M. oleifera’s aqueous extract inhibited measles at 0.125 and 0.063 g L-1, C. paridisi’s aqueous extract inhibited the virus at 0.031 g L-1. The n-hexane extract of B. Vulgaris was able to inhibit the virus at 0.125 g L-1, but none of the extracts of M. oleifera or C. paradise had an inhibitory effect against HSV-1.

Inhibitors of both adsorption/entry and post-infection inhibitors of the viruses were found in the results of the mechanism of action of the extracts on the replication cycle of the viruses. Terpenes, alkaloids, flavonoids, tannins, mixed and free anthraquinones, cardiac glycosides, and saponins were all found in the extracts after a phytochemical examination.

The measles virus, which is an enveloped RNA virus, as well as HSV-1, which is likewise enclosed but belongs to the DNA class of viruses, were both significantly inhibited by the extracts of the three plants: Bambusa vulgaris, Citrus paridisi, and Moringa oleifera, employed in this study. This shows that the extracts could potentially operate as anti-measles virus and anti-HSV-1 medicines due to their broad spectrum of activity against specific RNA and DNA viruses. Therefore, additional research aimed at identifying and isolating the active antiviral components of these three plants is advised. It is a good idea to suggest that these whole plants or their active parts be turned into medicines that could work as antiviral agents. This would make them cheaper for people in developing countries.

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Also, scientists from Kings University in Osun State and Ekiti State University in Ado Ekiti have confirmed that two Nigerian plants, alligator pepper (also called “grains of paradise”) and bamboo, can fight viruses.

The work was published in the African Journal of Plant Science. The researchers claim that ethanolic extracts of Bambusa vulgaris and Aframomum melegueta were created. Using standard laboratory methods, they were tested to see if they could stop the spread of three human viruses: measles, yellow fever, and polio.

Both extracts demonstrated antiviral activity against one or more viruses, according to the researchers. A. melegueta inhibited measles and yellow fever viruses at MICs of 125 and 250 g/ml, respectively, while B. vulgaris only inhibited the measles virus at a concentration of 62.5 g/ml. None of these extracts was effective against the poliovirus type 1 strain.

Also at the top of the list of herbal treatments for chicken pox and other skin conditions is a decoction made from neem leaves. The Meliaceae family includes neem, which is also known as dogonyaro in Nigeria and is botanically known as Azadirachta indica. The typical tree is the most well-known plant that has been shown to help treat chicken pox.

Neem extracts have been demonstrated to have anti-bacterial, anti-fungal, strong antiviral, and anti-cancerous effects up to this point. It has been discovered that neem works well as an antiseptic to treat viral infections, such as smallpox. Neem extracts have been demonstrated to have strong antiviral capabilities against various viruses, including herpes simplex virus type-1 infection and chicken pox, according to Indian researchers in a study published in the Journal of Biological Sciences. A recent study published in the International Journal of Clinical Nutrition (IJCN) found that Neem has chemicals that can wrap around viruses and stop them from spreading disease.

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Additionally, researchers have shown that using natural therapies can prevent and treat hepatitis B and C as well as liver damage in the nation’s population more affordably. Bitter leaf, Phyllanthus amarus, avocado, turmeric, garlic, and bitter kola is at the top of the list. The plant Phyllanthus amarus is a member of the Euphorbiaceae family. The Efik refer to it as oyomokeso amanke edem, while the Hausa refer to it as geeron-tsuntsaayee (birds millet), the Ibo (Asaba) name it buchi oro, the Ibo (Umuahia) call it ngwu, the Urhobo call it iyeke, and the Yoruba call it edem.

Curcuma longa, a plant that belongs to the ginger family (Zingiberaceae), produces turmeric as a spice. Atale pupa is the Yoruba name; gangamau is the Hausa name; nwandumo is the Ebonyi name; ohu boboch is the Tiv name; magina is the Kaduna name; Turi is the Niger State name, and onjonigho is the Cross River name (Meo tribe).

Additionally, Vernonia amygdalina water-based extract, which was discovered by Nigerian researchers, may be employed as an adjuvant in the treatment of HIV/AIDS patients. A recent study on the immunological effects of Vernonia amygdalina leaf extract and immune (nutritional supplement) on HIV-infected patients receiving highly active antiretroviral therapy (HAART) discovered that it could be used as a nutritional supplement in people with HIV or immunocompromised conditions such as cancer or diabetes.

The study’s conclusion in the Asian Pacific Journal of Tropical Biomedicine read, “The aqueous extract of Vernonia amygdalina (bitter leaf) and immunace, or both, have an immunological effect on HIV-infected individuals.” So, we think that either the V. amygdalina extract or immunace, or even both, could be used as an adjuvant in the treatment of HIV/AIDS patients.

The World Health Organization (WHO) and the Food and Agricultural Organization (FAO) have also backed several herbs and spices that have shown promise in treating opportunistic infections caused by viral infections without side effects.

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They have established the effectiveness of opportunistic diseases linked to HIV/AIDS in the treatment with the use of garlic, ginger, cloves, thyme, cayenne, basil, aloe vera, neem, lemon, and lemongrass. In a U.S. patent called “US 20070275085 A1,” a product made from neem is described as formulations and methods for treating HIV/AIDS.

Also, studies done in Nigeria under the direction of Prof. Maurice Iwu, a professor of pharmacognosy at the University of Nigeria Nsukka (UNN), Chief Executive Officer of the Bioresources Development Group (BDG), and former chairman of the Independent Election Commission (INEC), have supported the use of local foods like bitter kola, coconut oil, bitter leaf, Moringa oleifera, Sour sop, the mushroom Ganoderma lucidum, and

Additionally, another team of researchers has shown through clinical studies how polyherbal formulations comprised primarily of the bitter leaf can treat HIV, cancer, type 2 diabetes, tuberculosis, and the chronic form of hepatitis B and C co-infection. The Department of Histopathology and Cytology at the Jos University Teaching Hospital (JUTH) in Jos and the Halamin Herbal Centre in Abuja found that polyherbal preparations with bitter leaf as the active ingredient strengthen the immune system by controlling many cytokines and chemokines.

Sesame (Sesamum indicatum), bitter leaf, Aloe barbadensis (also called aloe vera), Saccharum officinarum (sugar cane), garlic, and Amaranthus caudatus (green amaranth, inine in Ibo, and tete abalaye in Yoruba) are also used in polyherbal formulations.

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BBNaija: Level 1 housemates win week 2 wager challenge

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Level 1 housemates of the ongoing television reality show, Big Brother Naija, season 7, on Friday won the week two wager challenge.
Biggie, the coordinator of the show after announcing the winner gave each housemate in the level 1 house “1,500 pocket naira”, which would be used to purchase their needs in the house.
The winning housemates: Diana, Sheggs, Bella, Doyin, Adekunle, Chomzy, Deji, Giddyfia, Hermes, Dotun, Allyson, Eloswag and Chichi were also rewarded with a pool party, to hold Aug.11.
yantv.ng reports that housemates in the two level houses participated in the challenge which had them create and present a sport that could become a worldwide phenomenon.
The level 1 housemates created the “Bum Ball” sport while the level 2 housemates came up with “Card Shot” sport.
Earlier, Biggie cautioned Danielle and Khalid over microphone infringement while Amaka, Beauty and Cyph were advised to participate in the morning workout, adding that the exercise was compulsory for all housemates.
yanstv.ng reports that 26 housemates are currently bidding for the grand prize of N100 million.

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BBNaija: 5 Ways To Vote For Your Favourite Housemates Nominated For Eviction

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Info Digital Africa, the Public Relations consulting firm for the ongoing television reality show, Big Brother Naija, has revealed five ways to vote for housemates nominated for eviction during the show.

The firm said this in a statement made available to newsmen on Thursday in Lagos.

Amaka, Christy-O, Cyph, Khalid and Phyna are the first five housemates up for possible eviction.

Voting which had been opened on Monday at 9.00pm for viewers to save their favourites from eviction, will close on Thursday at 9.00pm.

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The statement said that the voting process could be done through: voting on the website, mobile site, use of the MyDStv app, voting on the MyGOtv app and play games for additional votes through MyDStv or MyGOtv App.

“To vote on the website, all you need to do is register with your name, surname, year of birth, gender, location, and cell phone number.

“The website will give you 100 votes per round, website voting is open to over 45 countries across Africa.

“Voting through the mobile site will allow you to receive 100 votes per voting round when you register, it is also open to voting across over 45 countries continent-wide.

“Using the MyDStv app method is only open to active DStv subscribers and requires you to download the MyDStv app.

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“You will then receive the total votes allotted to your subscription package,” it said.

The statement said that premium subscribers would receive 2,500 votes, while compact plus and compact customers would receive 1,500 and 750 votes respectively.

Also, confam/family subscribers would get 500 votes, and yanga/access subscribers would receive 200 votes, as voting through the DStv app is open to 31 countries across Africa.

“For voting on the MyGOtv app, only active GOtv subscribers can access this voting platform, where votes are allocated based on subscription packages.

“The app is available to BBNaija fans who wish to vote for their favourite housemates on android and IOS.

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“GOtv Supa subscribers will receive 500 votes for each voting round, while those with the GOtv Max package will receive 350 votes.

“GOtv Jolli/Plus with active subscriptions will have 200 votes, voting through MyGotv App is only available in Nigeria, Ghana, Kenya, Malawi, Namibia, Uganda, and Zambia,” it said.

It said, for individuals who choose to vote through play games for additional votes through “the MyDStv or MyGOtv App”, the voting option was only available to active DStv subscribers with eligible packages.

“Check out how to get more votes by playing the games below: Download the MyDStv or MyGOtv App from the Google Play Store or the Apple App Store.

“Log in to the app by selecting your subscription country and using your surname, mobile number or smartcard/IUC number.

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“Once you have logged into your MyDStv or MyGOtv app account page, look for the “Explore More” button.

“Click on the “Play Now” option and follow the instructions to play the games, after playing each game, click “Vote Now” to convert your points to votes, or click on “More Games” to play more games.

“You can get up to 200 additional votes to save your favourite housemate,” it said. (NAN)

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Farm Cut Offers a Model for Growing Cannabis and Collaborating

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Farm Cut Offers a Model for Growing Cannabis and Collaborating

Collaboration instead of competition is uncommon and almost extinct in 2022, at the centre of late-stage capitalism. Farm Cut seeks to rectify that. While other businesses compete to have the best cannabis, the dankest ganja, the loudest buds, and to call anything else shwag, Farm Cut adopts a unique strategy by working together to cultivate the best.

Five family farms that makeup Farm Cut can be located in Northern California’s fertile and conducive to outdoor growing areas. It consists of Whitethorn Valley Farm, HappyDay Farms, Emerald Spirit Botanicals, Down Om Farms, and Briceland Forest Farm. Instead of growing cannabis under artificial settings, each cooperating farm concentrates on regenerative and organic processes. The farms also provide their neighbours with fresh products from the area, which fosters a sense of community and support.

Farm Cut is unique among its competitors because they don’t trim. You did read that correctly. The little sugar leaves that cover the buds are left in place by the farmers.

The thinking behind this audacious choice is explained by Daniel Stein of Briceland Forest Farm.

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He explained the method of removing the buds by running your fingers down the stems: “We actually don’t trim; Our process is that we buck it down off the stem after it’s fully dried.” After it has been bucked down, the cure takes place. When we are ready to package it, we remove any stems or larger leaves and simply brush it with gloves.

This technique produces a delicious and aromatic outdoor herb that has an added layer of weather resistance.

Depending on how it is stored, cannabis is susceptible to deterioration caused by elements like light and humidity. According to Stein, Farm Cut’s anti-trimming process keeps the plant’s terpenes and cannabinoids longer than trimming does. The small protecting leaves around the flower bud, known as the sugar leaves, are still present when the buds are presented by Farm Cut since that is how producers maintain them in their head stashes.

According to Stein, “We are trying to do this in the way that farmers preserve and keep their weed.” “When you trim it—I guess the best thing I can relate it to is, when you go to the grocery store, you wouldn’t buy a peeled banana or a peeled orange. It’s just ridiculous. They come with a natural, protective coat, and similar, that little bit of sugar leaf that’s on cannabis keeps it from hitting against other buds and moderates its moisture.”

Before rolling a joint, Stein advises cleaning the leaf matter off. After shaking the joint, throw the shake into an edible. It’s a win-win situation for everyone.

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In order to preserve the quality in regards to issues like moisture retention, Farm Cut only sells quarters and half-ounces rather than grams and eighths. They overfill the reusable jars with a little extra product to make up for the leaves that inevitability makes it into the bag in order to make sure that customers are still getting what they paid for. By doing it this way, you still get a ton of ganja deliciousness, and after the leaves are taken off, there is still a ton of product.

Farm Cut emphasizes more than just paying careful attention to prolonging the life of the flower by avoiding cutting. They also comprise a close-knit group of cannabis cultivators. The collective of farms can expand the variety of items they sell to merchants by cultivating several strains simultaneously on various farms because they all stand behind each other’s goods.

According to Stein, the camaraderie between farmers is really where this brand originated. “We’re all farms that share a lot of our ethos and how and why we grow. We’ve all either met each other as friends in life or through the cannabis industry, and we’ve all had these experiences of aligning with brands that don’t really represent us. They may help us sell flowers or whatever, but they don’t represent the morals, ethos, and quality of what we want to bring into the world.”

The farms that make up the neighbourhood of Farm Cut are all privately owned. Each one serves as a homestead for families with several generations and farm animals.

This group of farmers representing the same things coming together is quite special, according to Stein. “We have vegetables, too. We’re farmers, not growers. We don’t come from the indoor growing industry. We come from a relationship with plants to the earth and feel a responsibility to take care of the earth and our community. And part of that with the food is learning to connect to the land we live on in a way that creates something higher-quality than what would be grown on an industrial farm.”

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